Supramolecular Chemistry

chemical sciences

advanced

CH2_W11, CH2_U16

Completed basic courses in general, inorganic, physical and organic chemistry.

Supramolecular chemistry as science that studies complex molecular systems arising from the self-organization of molecules. Discussion of the types of interactions in supermolecules, research methods, types of supramolecular systems and their potential applications.

1. Concepts in supramolecular chemistry

2. The supramolecular chemistry of life

3. Cation-binding hosts

4. Binding of anions

5. Binding of neutral molecules, part 1

6. Binding of neutral molecules, part 2

7. Methods

8. Crystal engineering, part 1

9. Crystal engineering, part 2

10. Self-assembly

11. Artificial enzymes

12. Molecular devices

13. Molecular machines

14. Biological mimics

15. Concepts and perspectives for the nanoworld

Obligatory:

1. J. W. Steed, J. L. Atwood, Supramolecular Chemistry, John Wiley & Sons, Ltd 2000.

2. J.-M. Lehn, Chemia supramolekularna, IChF PAN, Warszawa 1993. (in Polish)

Supplementary:

1. O. Danylyuk, K. Suwinska, Solid-state interactions of calixarenes with biorelevant molecules. Chem. Commun. (2009) 5799-5813.

2. N. Shan, M. J. Zaworotko, The role of cocrystals in pharmaceutical science. Drug Discovery Today, 13 (2008) 440-–446.

3. H.-J. Schneider, A. K. Yatsimirsky, Selectivity in supramolecular host–guest complexes. Chem. Soc. Rev., 37 (2008) 263–277.

4. M. J. Zaworotko, Molecules to crystals, crystals to molecules ... and back again? Crystal Growth & Design, 7 (2007) 4-9.

5. C. B. Rodell, J. E. Mealy, J. A. Burdick, Supramolecular guest-host interactions for the preparation of biomedical materials. Bioconjugate Chemistry,26 (2015) 2279-2289.

6. A. S. Batsanov, Weak interactions in crystals: old concepts, new developments, Acta Cryst. E74 (2018) 570–574.

7. J. D. Dunitz, Weak interactions in molecular crystals. J. A. K. Howard et al. (eds.), Implications of Molecular and Materials Structure for New Technologies © Kluwer Academic Publishers 1999.

8. M. K. Corpinot and D.-K.Bučar, A Practical Guide to the Design of Molecular Crystals. Cryst. Growth Des. 19 (2019) 1426−1453.

Knowledge:

defines and distinguishes between supramolecular systems

indicates applications of supramolecular chemistry

explains the role of supramolecular chemistry in life processes

Skills:

classifies intermolecular interactions

analyzes the supramolecular systems

information lecture (conventional)

written exam

Assessment criteria

(5) - verification shows that without definable shortcomings the student defines and distinguishes supramolecular systems

(4.5) - verification shows that the student almost completely defines and distinguishes supramolecular systems, but does not meet the criteria for a higher grade

(4) - verification shows that the student largely correctly defines and distinguishes supramolecular systems, but does not meet the criteria for a higher grade

(3.5) - verification shows that the student correctly but inconsistently defines and distinguishes supramolecular systems, but does not meet the criteria for a higher grade

(3) - verification shows that in most test cases the student defines and distinguishes supramolecular systems, but does not meet the criteria for a higher grade

(2) - verification does not show that the student defines and distinguishes supramolecular systems, or that the student meets the criteria for a higher grade

(5) - verification shows that without clear deficiencies, the student explains the role of supramolecular chemistry in life processes

(4.5) - the verification shows that the student almost fully correctly explains the role of supramolecular chemistry in life processes, but does not meet the criteria for a higher grade

(4) - the verification shows that the student correctly explains the role of supramolecular chemistry in life processes, but does not meet the criteria for a higher grade

(3.5) - verification shows that the student correctly, but does not fully explain the role of supramolecular chemistry in life processes, but does not meet the criteria for a higher grade

(3) - verification shows that in the majority of test cases the student explains the role of supramolecular chemistry in life processes, but does not meet the criteria for a higher grade

(2) - verification does not show that the student explains the role of supramolecular chemistry in life processes or that the student meets the criteria for a higher grade

(5) - the verification shows that without definite shortcomings the student indicates the applications of supramolecular chemistry

(4.5) - verification shows that the student almost completely correctly indicates the use of supramolecular chemistry, but does not meet the criteria for a higher grade

(4) - the verification shows that the student applies correctly but inconsistently the application of supramolecular chemistry, but does not meet the criteria for a higher grade

(3.5) - verification shows that the student correctly indicates the use of supramolecular chemistry, but does not meet the criteria for a higher grade

(3) - verification shows that in the majority of test cases the student indicates the use of supramolecular chemistry, but does not meet the criteria for a higher grade

(2) - verification does not show that the student indicates the use of supramolecular chemistry or that the student meets the criteria for a higher grade

(5) - the verification shows that without definite shortcomings the student indicates the applications of supramolecular chemistry

(4.5) - the verification shows that the student almost fully predicts the properties of supramolecular systems, but does not meet the criteria for a higher grade

(4) - verification shows that the student predicts predominantly the properties of supramolecular systems, but does not meet the criteria for a higher grade

(3.5) - verification shows that the student predicts the properties of supramolecular circuits to a significant extent but does not consistently predict it, but does not meet the criteria for a higher grade

(3) - verification shows that in most test cases the student predicts the properties of supramolecular systems, but does not meet the criteria for a higher grade

(2) - verification does not show that the student predicts the properties of supramolecular systems, or that the student meets the criteria for a higher grade

(5) - verification shows that without intractable shortcomings the student classifies intermolecular interactions

(4.5) - verification shows that the student almost completely classifies intermolecular interactions, but does not meet the criteria for a higher grade

(4) - verification shows that the student correctly classifies intermolecular interactions, but does not meet the criteria for a higher grade

(3.5) - verification shows that the student correctly, but does not consistently classify intermolecular interactions, but does not meet the criteria for a higher grade

(3) - verification shows that in most test cases the student classifies intermolecular interactions, but does not meet the criteria for a higher grade

(2) - verification does not show that the student classifies intermolecular interactions or that the student meets the criteria for a higher rating

Final rating x is determined based on the value of:

st (w) = 5, if 4.5 <w; st (w) = 4.5, if 4.25 <w ≤ 4.5; st (w) = 4, if 3.75 <w ≤ 4.25; st (w) = 3.5, if 3.25 <w ≤ 3.75; st (w) = 3, if 2.75 <w ≤ 3.25; st (w) = 2, if w ≤ 2.75

and on the basis of the following rule:

● if each of the final marks for related activities is positive and their average is y, then x is determined by the formula x = st ((y + z) / 2), where z is the weighted average of the assessments carried out in which the weightings examinations are 2, and the grades from other forms of verification are equal to 1

● if at least one final grade of related activities is 2, then x = 2