(in Polish) Molecular basic of neurodegeneration

elementary

B.W21.

B.W30.

C.W32.

C.W41.

E.W15.

A course of “Molecular basis of neurodegeneration” includes lectures that present the current knowledge on molecular mechanisms of neurodegeneration. The main processes leading to neuronal degeneration are discussed, including autoimmune reactions, disturbances of the ubiquitin-proteasome system, oxidative stress, inflammation, autophagy, and metals brain accumulation. The role of individual mechanisms in the pathogenesis of the major and most common neurodegenerative disorders namely, Alzheimer’s and Parkinson;s diseases, Huntington’s disease, multiple sclerosis, and prion diseases. The lecture course ends with themes on molecular biomarkers and neuroprotection strategies of neurodegenerative disease.

The student should acquire knowledge of: methods of communication between cells, as well as between the cell and the extracellular matrix, as well as signaling pathways in the cell and examples of disorders in these processes leading to the development of cancer and other diseases; relationships between factors disturbing the balance of biological processes and physiological and pathophysiological changes; external and internal pathogens, modifiable and non-modifiable; basic directions of therapy development, in particular possibilities of cell therapy, gene and targeted therapy in specific diseases; basic concepts of pathogenesis of mental disorders.

Obligatory sources:

Molecular Aspects of Neurodegeneration and Neuroprotection. Ed. Akhlaq A. Farooqui,Tahira Farooqui. Bentham Science Publishers. 2011. ISBN: 978-1-60805-092-5

Molecular Mechanisms of Neurodegenerative Diseases

Editors: Chesselet, Marie-Francoise (Ed.) 2001. Humana Press Inc., Totowa, NJISBN 978-1-59259-006-3

Additional:

Scientific papers suggested by the lecturer and web pages (so called “links” i.e. www addresses for individual papers of web pages are given during lectures)

Knowledge

B.W21.

knows the ways of communication between cells, as well as between the cell and the extracellular matrix as well as signaling pathways in the cell and examples of disorders in these processes leading to the development of cancer and other diseases

B.W30.

knows the relationship between factors that disturb the balance of biological processes and physiological and pathophysiological changes

C.W32.

lists external and internal pathogens, modifiable and non-modifiable

C.W41.

knows the basic directions of therapy development, in particular the possibilities of cell therapy, gene and targeted therapy in specific diseases

E.W15.

knows the basic concepts of pathogenesis of mental disorders

Seminar

Participation in classes

15 h

Preparation for the exam

30 h

Participation in consultations

5 h

Sum

50 h

Number of ECTS (50 hours / 30 (25) hours = 1 ECTS)

2 ECTS

Total ECTS points:

2 ECTS

The student’s work is verified through written test – verification of education effects by written test partially one-choice examination and open question test. Final test appraisal (partially one-choice examination and open question test) to get a pass on third min. 50% is required, for third plus – 60%, for second: 70%, for second plus: 80%, for first: 90%.

unsatisfactory (n / a -2)

student does not have knowledge in the field provided for in the learning outcomes (B.W21., B.W30., C.W32., C.W41., E.W15.)

satisfactory (dst .: 3)

student has a small extent to the extent provided in the learning outcomes (B.W21., B.W30., C.W32., C.W41., E.W15.)

good (db: 4)

student has sufficient knowledge in the field provided for in the learning outcomes (B.W21., B.W30., C.W32., C.W41., E.W15.)

very good (very good: 5)

student has full knowledge in the field provided for in the learning outcomes (B.W21., B.W30., C.W32., C.W41., E.W15.)