Print syllabus(in Polish) Genetics
General data
| Course ID: | WMCM-NU-GE-CW-1-2 |
| Erasmus code / ISCED: | (unknown) / (unknown) |
| Course title: | (unknown) |
| Name in Polish: | Genetics |
| Organizational unit: | Faculty of Medicine. Collegium Medicum |
| Course groups: | |
| ECTS credit allocation (and other scores): |
(not available)
|
| Language: | English |
| Subject level: | elementary |
| Learning outcome code/codes: | A.W10, A.W11, A.W12, A.U6, A.U13 |
| Short description: |
The student should acquire knowledge of: genome, transcriptome and human proteome functions and basic methods used in their study; DNA replication, repair and recombination processes, transcription and translation, and DNA, RNA and protein degradation; concept of gene expression regulation; basic concepts in genetics; phenomena of gene coupling and interaction; the correct human karyotype and different types of sex determination; structure of chromosomes and molecular basis of mutagenesis; principles of inheritance of different numbers of traits, inheritance of quantitative traits, independent inheritance of traits, and inheritance of non-nuclear genetic information; genetic conditions of human blood groups and serological conflict in the Rh system; aberrations of autosomes and heterosomes that cause diseases, gene mutations responsible for hereditary and acquired diseases. |
| Full description: |
Lecture: 1. Genetics as a science, the most important discoveries / DNA structure, genes, genetic code, gene expression: transcription in Procaryota, transcription in Eucaryot 2. Ribonucleic acid: transfer (tRNA), ribosomal (rRNA), informative (mRNA); splicing, alternative splicing, RNA editing. Epigenetic regulation of gene expression. 3. Translation [translation in Procaryota, translation in Eucaryot, stages: initiation, elongation, termination, post-translational modifications] / DNA replication [replication in Procaryota, replication in Eucaryot] 4. Mutations: gene level mutations, chromosomal mutations 5. Diseases caused by gene mutations, diseases caused by chromosomal mutations 7. Mutagens and DNA repair 8. Eukaryotic viruses [viral genomes, structure of viruses, replication strategies, DNA viruses, RNA viruses, retroviruses] 9. Basics of Mendelian genetics [basic assumptions, one-character crosses, heterozygous recognition, multiple alleles] 10. Mendelian genetics, part II [two-character crosses, epistasis, Mendel's laws, interpretation of results]; T. Morgan's chromosomal theory of heredity 11. Sex determination in Eukaryotes / sex-linked inheritance 12. Types of inheritance in Eukaryotes: autosomal dominant, autosomal recessive, mitochondrial, multifactorial 13. Methods of genome research [genetic maps, physical maps, sequential analysis, gene location; analysis of selected markers - candidates, analysis of markers covering the entire genome, so-called GWAS (Genome – WideAssociationStudy); HapMap project] 14. Genetic and environmental factors important in shaping the phenotype of the disease Practical exercises Genetic crosses: autosomal dominant inheritance, autosomal recessive inheritance, sex-linked recessive inheritance, sex-related dominant inheritance, epigenetic inheritance, mitochondrial inheritance; Rules for the description of gene mutations Principles of karyotype description Inheritance of human blood groups (ABO system, Lewis system, Kell system, Rh) Fundamentals of diagnostics of gene and chromosomal mutations, responsible for hereditary and acquired diseases, including cancer Types of biological materials used in genetic diagnostics; rules for collecting, collecting and transporting material for testing |
| Bibliography: |
1. Genetyka. Krótkie wykłady; H.L. Fletcher, G.I. Hickey, P.C. Winter; Wydawnictwo Naukowe PWN, 2011. 2. Genetyka molekularna; red. Piotr Węgleński; Wydawnictwo Naukowe PWN, 2012 (copyright 2006). 3. Genomes. T. A. Brown. 4. Genetyka ogólna – skrypt do ćwiczeń dla studentów biologii. A. Sadakiewicz-Chudy, G. Dabrowska, A. Goc, , Wydawnictwo Uniwersytetu Mikołaja Kopernika, Toruń 2004. 5. Orzeszko-Rywka A., Rochalska M., Przewodnik do ćwiczeń z genetyki, Wydawnictwo SGGW, Warszawa 2007 6. Genetics, Revised Edition. Vipond, Karen. Lantern Publishing. 2013 7. Kapur & Suri'S Basic Human GeneticsPaperback – 2016 by Trivedi Dipali J (Author) Jaypee Brothers Medical Publishers; third edition (2016) ISBN-13: 978-9352500277 8. Human Genetics Paperback – Import, 23 Nov 2009 by S. D. Gangane (Author) ISBN-13: 978-8131211281 |
| Efekty kształcenia i opis ECTS: |
Knowledge A.W10. discusses the functions of the genome, transcriptome and human proteome, and basic concepts of regulating gene expression, including epigenetic regulation; A.W11. describes the structure of chromosomes and the molecular basis of mutagenesis; knows the metabolic profiles of basic organs; A.W12. lists the rules for inheriting different numbers of traits, inheriting quantitative traits, independent inheriting traits, and inheriting non-nuclear genetic information; Skills A.U6. estimates the risk of disclosure of a given disease based on the principles of inheritance and the impact of environmental factors; A.U13. uses knowledge of genetically determined diseases in cancer prevention and prenatal diagnosis |
| Assessment methods and assessment criteria: |
Obtaining a positive assessment is conditioned by: attendance at least 90% of all classes and a positive assessment of partial colloquia in a test form, carried out after each exercise, covering questions from the material of previous exercises; student receives a grade from the colloquium according to the following point thresholds: 51 - 60% - sufficient 61 - 70% - a sufficient plus 71 - 80% - good 81 - 90% - a good plus 91 - 100% - very good The final grade is the arithmetic average of all partial grades. |
| Practical placement: |
not applicable |
Copyright by Cardinal Stefan Wyszynski University in Warsaw.
